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Acute Leukemias IX

Author : Wolfgang Hiddemann,T. Haferlach,Thomas Büchner,J. Ritter,M. Unterhalt
Publisher : Springer Science & Business Media
Release : 2012-12-06
Category : Medical
ISBN : 9783642593581
File Size : 36,8 Mb
Total Download : 515


Book Summary: Acute Leukemias IX provides an extended and thorough overview of recent developments in cell biology and experimental therapy for acute leukemias. Following the tradition of the Acute Leukemias series since 1987, this book bridges the gap between basic research and clinical studies and emphasizes that both aspects are equally necessary to achieve improvements, not only in understanding the disease but also in providing better therapy. As a forum for world-wide activities in the field of acute leukemias the volume contains invaluable contributions that provide the reader with new, previously unpublished information.

Deoxynucleoside Analogs in Cancer Therapy

Author : Godefridus J Peters
Publisher : Springer Science & Business Media
Release : 2007-11-07
Category : Medical
ISBN : 9781597451482
File Size : 41,9 Mb
Total Download : 652


Book Summary: Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for the treatment of many malignancies, both solid tumors and hematological disorders. In the latter diseases, cytarabine has been the mainstay of treatment of acute myeloid leukemia. Although many novel compounds were synthesized in the 1980s and 1990s, no real improvement was made. However, novel technology is now capable of elucidating the molecular basis of several inborn errors as well as some specific malignancies. This has enabled the synthesis of several deoxynucleoside analogs that could be applied for specific malignancies, such as pentostatin and subsequently chlorodeoxyadenosine (cladribine) for the treatment of hairy cell leukemia. Already in the early stage of deoxynucleoside analog development, it was recognized that several of these compounds were very effective in the treatment of various viral infections, such as for the treatment of herpes infections. This formed the basis initially for the design of azidothymidine and subsequently many other analogs, which are currently successfully used for the treatment of HIV infections. As a spin-off of these research lines, some compounds not eligible for development as antiviral agents appeared to be very potent anticancer agents. The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy

Author : Ganji Purnachandra Nagaraju
Publisher : Academic Press
Release : 2019-02-26
Category : Science
ISBN : 9780128176627
File Size : 52,8 Mb
Total Download : 225


Book Summary: Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

Complexity Applications in Language and Communication Sciences

Author : Àngels Massip-Bonet,Gemma Bel-Enguix,Albert Bastardas-Boada
Publisher : Springer
Release : 2019-01-11
Category : Language Arts & Disciplines
ISBN : 9783030045982
File Size : 40,8 Mb
Total Download : 601


Book Summary: This book offers insights on the study of natural language as a complex adaptive system. It discusses a new way to tackle the problem of language modeling, and provides clues on how the close relation between natural language and some biological structures can be very fruitful for science. The book examines the theoretical framework and then applies its main principles to various areas of linguistics. It discusses applications in language contact, language change, diachronic linguistics, and the potential enhancement of classical approaches to historical linguistics by means of new methodologies used in physics, biology, and agent systems theory. It shows how studying language evolution and change using computational simulations enables to integrate social structures in the evolution of language, and how this can give rise to a new way to approach sociolinguistics. Finally, it explores applications for discourse analysis, semantics and cognition.

Phosphoproteins: Advances in Research and Application: 2011 Edition

Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
Category : Medical
ISBN : 9781464933219
File Size : 40,8 Mb
Total Download : 237


Book Summary: Phosphoproteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Phosphoproteins in a concise format. The editors have built Phosphoproteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phosphoproteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phosphoproteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Exports and Technology

Author : Kirsty Hughes
Publisher : CUP Archive
Release : 1986-08-14
Category : Business & Economics
ISBN : 0521320364
File Size : 22,9 Mb
Total Download : 325


Book Summary: This book analyses the relationships between technological advancement and innovation, and trade performance. It concentrates, in particular, on the contribution of research and development expenditures, and skilled labour, to exports. It examines what determines expenditure on R & D, and whether there is a chain of causation from exports to R & D. The book reviews and develops the existing literature both on the relationship between technology, skill and trade flows, and on the determinants of research and development. It also looks at relative technological competitiveness and export performance in the USA, Japan, West Germany, the UK and France. It examines empirical evidence for the theories analysed on the basis of cross-section studies of UK manufactured exports, imports, and net trade; of changes in the trade variables, and of R & D spending. A comparative study of the UK and West Germany is also provided.

Current Trends in the Study of Bacterial and Viral Fish and Shrimp Diseases

Author : Leung Ka Yin
Publisher : World Scientific Publishing Company
Release : 2004-10-04
Category : Science
ISBN : 9789813106239
File Size : 46,8 Mb
Total Download : 111


Book Summary: The important volume summarizes the current trends and developments in the study of bacterial and viral fish diseases. Books on these subjects are few and relevant review articles are mostly outdated. This volume will thus serve as a platform for scientists and aquaculturists to understand the current limitations as well as new developments so that fish health and disease control can advance to new heights. The first section provides readers with an overview of the bacterial and viral diseases and the current understanding of innate immunity and interactions with pathogens. Section II includes case studies, where three pathogens are presented, namely two bacteria (Aeromonas hydrophila and Vibrio anguillarum, the common causes of bacterial diseases in freshwater and marine aquaculture, respectively) and the white spot syndrome virus (an important viral disease in shrimp). These case studies serve as models for the study of various bacterial and viral diseases. Section III presents new platform technologies that are widely used in the study of human pathogens. It aims to spur fish biologists to use modern and cutting edge technologies for their studies so that the study of fish disease can move into the mainstream and focus on the basics. The final section is on marine biotechnology, discussing biotechnology products that are urgently needed for the aquaculture industry — spin-offs from basic research, including diagnostics, immunotherapy and vaccine development, and the use of probiotics.

Knowledge Engineering Tools and Techniques for AI Planning

Author : Mauro Vallati,Diane Kitchin
Publisher : Springer Nature
Release : 2020-03-25
Category : Computers
ISBN : 9783030385613
File Size : 50,8 Mb
Total Download : 309


Book Summary: This book presents a comprehensive review for Knowledge Engineering tools and techniques that can be used in Artificial Intelligence Planning and Scheduling. KE tools can be used to aid in the acquisition of knowledge and in the construction of domain models, which this book will illustrate. AI planning engines require a domain model which captures knowledge about how a particular domain works - e.g. the objects it contains and the available actions that can be used. However, encoding a planning domain model is not a straightforward task - a domain expert may be needed for their insight into the domain but this information must then be encoded in a suitable representation language. The development of such domain models is both time-consuming and error-prone. Due to these challenges, researchers have developed a number of automated tools and techniques to aid in the capture and representation of knowledge. This book targets researchers and professionals working in knowledge engineering, artificial intelligence and software engineering. Advanced-level students studying AI will also be interested in this book.